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近日，创新医疗器械企业帕母医疗宣布完成近1亿美元C轮融资。本轮融资由启明创投共同领投。融资资金将主要用来推动帕母医疗的全球临床、海外业务及战略发展规划。

值得一提的是，本轮融资两次超募，是近年来亚太地区创新医疗器械领域最大规模的市场化融资，意味着顶尖投资机构充分信任帕母医疗的国际化战略和专业能力。

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中国原创器械领航者

帕母医疗创立于2013年，专注于为肺高压和心衰领域提供突破性疗法，提升患者的生命复原力。作为写入国际指南的中国原创器械领航者，帕母医疗凭借其深厚的临床资源，专注于突破性技术的科学探索及国际视野的商业化开拓，力图在心衰不同阶段创造更优的解决方案以期延缓和改善心衰患者的疾病进展，以科技创新力量构建心衰行业治疗新格局。

帕母医疗核心团队由一批在心肺领域拥有深厚专业知识和丰富临床资源的专家组成。帕母医疗董事长、执行主席兼总裁Cynthia Chen曾任职于世界卫生组织（WHO）瑞士日内瓦总部及美敦力中国。帕母医疗执行董事兼首席执行官连佳（Jessie Lian）曾任职于美国强生公司、嘉德诺，后担任美国康蒂思医疗器械公司亚太总裁兼中国总经理。凭借着丰富的行业经验和敏锐的市场洞察力，Cynthia与Jessie联合顶尖的心肺领域医生开启了该领域开创性的探索。

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PADN登陆欧美顶级医疗机构

帕母医疗的原研核心技术及产品“经皮肺动脉去神经术（简称PADN）”系列导管和主机是全球首个中国率先获批的肺高压微创介入疗法产品。肺高压（Pulmonary Hypertension，PH）发展严重会引起心衰和死亡，被称为“心血管中的癌症”，且治疗手段非常有限，目前以药物为主。PADN用射频消融术阻断肺血管内膜交感神经，从而有效降低肺动脉压力，延缓疾病进程。

过去8年，帕母医疗PADN相关临床试验每一年都登上全美心血管领域最具影响力的峰会——美国经导管心血管治疗学术大会（Transcatheter Cardiovascular Therapeutics，TCT），发表超过15篇心血管顶刊论文，包括但不限于JACC、 EuroInvervention、JACC HF等，这标志着这项中国原创技术已经逐步获得世界肺高压治疗学术界和临床界的肯定。

2024年10月，帕母医疗一行受邀在美国梅奥诊所（Mayo Clinic）完成了关于帕母医疗的PADN的首次北美临床培训。作为国际上享有盛誉的顶尖医疗机构，梅奥诊所已经连续六次被《新闻周刊（Newsweek）》评为全球第一医疗机构。梅奥诊所也是世界上采用新型医疗手段与技术的领先者。帕母医疗此行，意味着正将“中国方案”推向全球医疗创新高地。这也是历史上首次“中国团队、中国PI、中国方案”一同进入梅奥诊所。

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中国医疗器械原创创新惠及全球

除了在中国商业化进程如火如荼地开展，帕母医疗在全球还有多个正在进行的临床项目。在中国，针对慢性心衰合并2型肺高压适应症的大型注册临床，正在与30多家顶级三甲医院合作进行中，目前即将收尾。在欧洲、亚洲多家顶尖医院和研究机构的支持下，PADN治疗慢性心衰合并2型肺高压的国际多中心临床研究入组顺利，已入组和即将入组的中心覆盖葡萄牙、意大利、瑞士、希腊、塞尔维亚、格鲁吉亚、新加坡、马来西亚等国家。同时，两项FDA全球多中心临床试验也即将在美国展开。

帕母医疗团队表示：“在人工智能领域，中国技术DeepSeek横空出世，展现出全球影响力。而在医疗器械领域，帕母医疗则是中国医疗器械创新飞速崛起的典型代表。过往，中国医疗器械企业学习国外医疗技术，只能亦步亦趋地跟跑，而现在中国医疗器械企业站在创新的源头，在肺高压及心衰的非药物治疗、介入治疗领域引领全球的发展方向。帕母医疗打破了中国器械企业出海以经销商和渠道合作商业化为主的传统模式，让来自中国的创新技术和产品逐步走向国际舞台。”

启明创投主管合伙人胡旭波表示：“帕母医疗在肺高压和心衰介入治疗领域取得的创新突破令人瞩目，其自主研发的PADN技术，不仅在中国内地、中国香港和中国澳门已开始商业销售，还于2024年开启了国际化进程，在葡萄牙、塞尔维亚、格鲁吉亚、东南亚等地进行全球多中心临床试验。继成功获得FDA突破性器械认证后，全球临床的开展进一步证明了该技术的全球领先性和临床价值。启明创投作为医疗健康领域的长期投资者，始终致力于支持具有全球视野的创新企业，我们非常看好帕母医疗在肺高压和心衰领域的巨大潜力，并将全力支持帕母医疗的国际化拓展和商业化落地，共同推动中国原创技术走向世界，为全球肺高压及心衰患者带来新的希望。”

本轮融资由启明创投和老股东礼来亚洲共同领投，现有投资人奥博资本（OrbiMed）、高榕创投超额追加投资。

Pulnovo Medical Announces Closing of Nearly $100 Million Series C Financing Co-led by Qiming Venture Partners 

Pulnovo Medical, a globally recognized pioneer in medical devices for pulmonary hypertension (PH) and heart failure (HF), has announced the closing of nearly $100 million Series C financing. This round was co-led by Qiming Venture Partners. The proceeds will be used to advance Pulnovo Medical's global clinical trials, international business expansion and strategic initiatives.

The financing round was oversubscribed by two times, marking one of the largest fundraises in the Asia-Pacific innovative medical device sector in recent years. This reflects leading institutions' confidence in Pulnovo Medical's global strategy and technical capabilities.

Founded in 2013, Pulnovo Medical is a pioneering medtech company recognized in international guidelines. The company leverages its extensive clinical expertise to drive scientific advancements and global commercialization. The company focuses on developing superior therapeutic solutions for various stages of heart failure to enhance patient outcomes.

Pulnovo Medical's core product, PADN (pulmonary artery denervation) technology, is the world's first minimally invasive treatment for PH to receive market approval. PH is a condition that can lead to heart failure and mortality, with limited treatment options. PADN uses radiofrequency ablation to target the pulmonary vascular endothelial sympathetic nerve, effectively reducing pulmonary artery pressure and slowing disease progression.

PADN received FDA Breakthrough Device designation for Group I, Group II, and Group IV PH in 2021. PADN was included in European Society of Cardiology and European Respiratory Society Guidelines in 2022. In 2023, Pulnovo Medical achieved the Humanitarian Use Exemption Device designation for Group I PH. The RF catheter and RF generator received market approval in China in late 2023, becoming the first commercially available interventional device in the field globally. In 2024, Pulnovo Medical's accessory product, the 9F sheath, received FDA clearance.

Cynthia Chen, Chairlady, Executive Chairwoman and President of Pulnovo Medical, announced that the proceeds of this round will support two upcoming FDA trials for Group I PH (pulmonary artery hypertension) and Group II PH (chronic heart failure combined with PH) planned this year. Under the leadership of the executive team, the company has transformed from a laboratory to a globally structured firm with offices in the US, Singapore, as well as Hong Kong and four cities in Chinese Mainland, including Beijing and Shanghai.

William Hu, Managing Partner of Qiming Venture Partners, said, "Pulnovo Medical's breakthroughs in interventional treatments for pulmonary hypertension and heart failure are impressive. The company's PADN technology is now commercially available in Chinese Mainland, Hong Kong, and Macau, and in 2024, global multicenter trials were initiated in Portugal, Serbia, Georgia, and Southeast Asia. Following the FDA Breakthrough Device designation, the global clinical trials further validate the technology's leadership and clinical value. As a long-term healthcare investor, Qiming is committed to supporting innovators with global visions. We are confident in Pulnovo Medical's potential and will support its international expansion and commercialization, bringing new hope to patients worldwide."

This round was co-led by Qiming Venture Partners and existing shareholder Lilly Asia Ventures, with existing investors OrbiMed and Gaorong Ventures participating on a super pro-rata basis.